HIGHLIGHTS: Matthew Stafford's best throws from 3-touchdown game vs. 49ers in Week 5

Los Angeles Rams quarterback Matthew Stafford's best throws from his three touchdown game vs. the San Francisco 49ers during Week 5 of the 2025 NFL season.

Los Angeles Rams head coach Sean McVay and quarterback Matthew Stafford address the media following 23-26 overtime loss to the San Francisco 49ers.

Watch the Los Angeles Rams' highlights against the San Francisco 49ers in Week 5 of the 2025 NFL season.

Los Angeles Rams inside linebacker Nate Landman (0:00), outside linebacker Byron Young (1:15), wide receiver Davante Adams (2:55), running back Kyren Williams (4:54), and wide receiver Puka Nacua (6:51) react to tonight's loss to the San Francisco 49ers.

Every catch from Los Angeles Rams wide receiver Puka Nacua's 10-reception game vs. the San Francisco 49ers during Week 5 of the 2025 NFL season. Nacua becomes the first player with over 50 catches through the first five games of an NFL regular season.

Los Angeles Rams quarterback Matthew Stafford torpedoes a 38-yard ball to wide receiver Tutu Atwell in overtime matchup against the San Francisco 49ers.

Los Angeles Rams running back Kyren Williams best plays from his two touchdown game vs. the San Francisco 49ers during Week 5 of the 2025 NFL season.

Los Angeles Rams kicker Joshua Karty notches a 48-yard game-tying field goal to send them into overtime against the San Francisco 49ers at SoFi Stadium.

Los Angeles Rams quarterback Matthew Stafford finds wide receiver Davante Adams wide open downfield for an 18-yard reception against the San Francisco 49ers at SoFi Stadium.

Los Angeles Rams linebacker Josaiah Stewart blocks San Francisco 49ers quarterback Mac Jones' pass for a near interception at SoFi Stadium.

Los Angeles Rams running back Kyren Williams catches for an 8-yard touchdown against the San Francisco 49ers at SoFi Stadium.

Los Angeles Rams quarterback Matthew Stafford slings a 26-yard dot to wide receiver Davante Adams against the San Francisco 49ers at SoFi Stadium.

Los Angeles Rams wide receiver Puka Nacua catches a 9-yard ball from quarterback Matthew Stafford to mark his 50th reception of the 2025 season during their Week 5 matchup against the San Francisco 49ers at SoFi Stadium.

Los Angeles Rams linebacker Nate Landman tackles San Francisco 49ers running back Christian McCaffery to force a fourth down.

Los Angeles Rams wide receiver Puka Nacua catches for a 1-yard touchdown against the San Francisco 49ers at SoFI Stadium.

Los Angeles Rams wide receiver Puka Nacua pushes for extra yardage on 16-yard catch and run from quarterback Matthew Stafford against the San Francisco 49ers at SoFi Stadium.

Los Angeles Rams quarterback Matthew Stafford uncorks a 35-yard ball to wide receiver Tutu Atwell who rings it in under pressure against the San Francisco 49ers at SoFi Stadium.

Los Angeles Rams tight end Davis Allen corrals a 20-yard pass from quarterback Matthew Stafford against the San Francisco 49ers at SoFi Stadium.

Los Angeles Rams quarterback Matthew Stafford finds wide receiver Jordan Whittington downfield for a 22-yard gain against the San Francisco 49ers at SoFi Stadium.

Los Angeles Rams running back Kyren Williams prances into the end zone off a 14-yard pass from quarterback Matthew Stafford against the San Francisco 49ers at SoFi Stadium.

Los Angeles Rams rookie tight end Terrance Ferguson makes a contested 21-yard grab from quarterback Matthew Stafford for his first career reception during the Rams' Week 5 matchup against the San Francisco 49ers.

On today's Digital Pregame Show presented by Little Ceasars, J.B Long, D'Marco Farr and staff writer Stu Jackson preview the Los Angeles Rams' Week 5 matchup against the San Francisco 49ers. The trio discuss key players to watch, game predictions, and more. Tune in for kickoff at 5:15pm PT on Amazon Prime Video.

In this week's new episode of Between The Horns, Camryn Irwin sits down with J.B. Long and D'Marco Farr to preview the Los Angeles Rams' matchup against the San Francisco 49ers. Watch the trio discuss keys to victory, break down the run defense against running back Christian McCaffrey, and more.

Los Rams de Los Ángeles se enfrentan a los 49ers de San Francisco en el SoFI Stadium. Mira el tráiler del juego de esta semana para prepararte para el duelo este jueves a las 5:15pm PT en Amazon Prime Video.

The Los Angeles Rams face off against their NFC West rivals, the San Francisco 49ers at SoFi Stadium. Watch this week's game trailer in preparation for Thursday's primetime matchup at 5:15pm PT on Amazon Prime Video.