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SoFi Stadium under the lights: Rams & Niners square off on Thursday Night Football | Game Preview

No one does it better on short weeks – especially when it comes to home back-to-backs.

In each of the past two seasons, defending home turf twice in a span of five days has changed the course of the Los Angeles Rams season.

In 2023, coming back from Baltimore after an overtime defeat at 6-7, LA buckled down and beat the Commanders and Saints on their way to four straight wins to earn a playoff spot.

Then again last season, in the depths of 1-4, we knew they'd have to rally coming out of the bye with home dates against the Raiders and Vikings. The Rams won them both and set a course for a return trip to the postseason.

Now, having prevailed over previously undefeated Indianapolis, division play arrives – rivalry style.

Thursday's winner will seize control of the NFC West at 4-1.

Bumps and Bruises

This matchup is full of mystery in terms of availability. From the opposing quarterback to many of his top targets, it's unclear which version of the 49ers the Rams will see come Thursday night.

Camryn Irwin captained this week's Between the Horns, as we talked through takeaways from beating the Colts and what LA might see from San Francisco.

Fool's Gold

With the 49ers passing game injured and in flux, all eyes will be on Christian McCaffrey. He and the Niners haven't scored a rushing touchdown so far. In fact, they're hardly recognizable, ranking 29th in the NFL in rushing DVOA.

But that's fool's gold. It's only a matter of time until it clicks for a Kyle Shanahan run game. Plus, McCaffrey's off to the best start of his career as a pass-catcher.

Tyler Davis and his running mates have kept two of the league's best backs in check the last couple weeks – Saquon Barkley and Jonathan Taylor.

The gauntlet continues with McCaffrey… and then Derrick Henry.

Les is More

Rams GM Les Snead pinched hit for Sean McVay on the coach's show, as he often does on short weeks.

We discussed Puka Nacua's torrid start as well as all the things he's doing without the ball in his hands.

"There's an element of Larry Csonka there," Snead said of Nacua's playstyle, likening LA's newest 24-year-old American Gladiator to the Dolphins Hall of Fame fullback.

In all four games so far, opponents have committed their top corner to Davante Adams. At what point might Nacua's record-setting pace command more attention? After all, he's the only player in NFL history to rack up 500 receiving yards through four games twice in his career.

The problem is, Nacua's willingness to mix it up in the running game and scratch up his facemask makes it difficult to assign a Derek Stingley Jr. or Quinyon Mitchell to him for a full day.

Of note this week, San Francisco has been playing Upton Stout in the slot. The 100th overall selection in this year's draft stands only 5-foot-9 and 182 pounds and is grading out as the 82nd-rated corner (out of 102) in the NFL. On paper, that's advantage Rams.

News & Notes

On a short week, let's rip through our shortlist of research nuggets that matter.

The Rams have won three in a row against their fiercest rival, their longest winning streak since taking six straight from 1999-2001. The disclaimer here: LA trailed going to the fourth quarter of all three.

According to ESPN, the 49ers have generated pressure on only 18.5% of opponent drop-backs, the lowest rate in the NFL. Without Nick Bosa (out for season with a torn ACL), they hardly bothered Trevor Lawrence in a home loss to the Jags last Sunday. Stafford has been elite when kept clean, and is coming off a heater – on the field and on the mic.

As of this writing, we're uncertain about the game status of his counterpart, Brock Purdy. No longer the best bargain in professional sports, the Niners quarterback has thrown multiple interceptions in both games he's played this season and 3 straight games dating back last season. Kam Curl got in the pick column last week; let's see if it's finally Quentin Lake's turn in prime time, or perhaps Emmanuel Forbes Jr.?

The deluge of Nacua stats has been staggering. I'm resisting the urge to inundate you with more in this column. But it's worth watching that with eight more receptions on Thursday, the third-year pro would eclipse Cooper Kupp (2022, 49) for the most receptions through the first five contests of a season in NFL history.

Alright, one more: Nacua has already surpassed Hall of Famer Isaac Bruce for most catches by a Ram through three seasons. And yes, I'm aware that he's only four games into his third season and missed six games (and parts of others) last year due to injury/rest/ejection. It's dumbfounding.

Meantime, Kyren Williams is fast approaching 3,000 career rushing yards. Just 115 shy of that milestone, it would be nice to see him dominate and race right through that mark at home against a rival. He's produced at least 100 scrimmage yards in all three career games versus the Niners.

Did you know the Rams have the third-most efficient running game in the league? The Nacua 45-yard touchdown was a shot in the arm, but still. As much as the offensive line has struggled in pass protection, let's give them their flowers for keeping LA on track on the ground.

One month in, Stafford is leading the NFL in deep passing and passing under duress, according to NextGen Stats. It's too early for conversations about individual awards, but if he's lights out on Thursday, I'm going to start thinking some thoughts.

It was a nice bounce-back performance for the field goal unit last Sunday, running a clean operation for Joshua Karty. That allows us to shine the spotlight once again on his other main responsibility. Of Karty's 20 kickoffs, 11 have resulted in starting field position at or inside the 20. No other kicker has done that more than 6 times so far this season, per Wyatt Miller. Whereas the Rams are second-best (behind Carolina) at pinning kick returners deep, the 49ers are the worst at it, per NFL Research.

I found this odd, but true: This is only the third time the 49ers have had a winning record through four games under Shanahan.

Los Angeles Rams
Table - Injury report
PlayerInjuryGame status
NFL CAREER


Has played in 138 regular season games (127 starts) and recorded 386 receptions for 3,949 yards and 27 touchdowns during the regular season in his eight-year NFL career.
Has appeared in 15 postseason matchups (13 starts), the ninth-most postseason starts in franchise history, and notched 35 receptions for 386 yards and two touchdowns. 
Is the Rams all-time leader in touchdowns, receptions, and receiving yards for tight ends.
Among active tight ends, Higbee currently ranks 11th in receptions, 13th in receiving yards and tied for 11th in receiving touchdowns. 
Among all Rams players in postseason action, ranks seventh in receptions (35) and ninth in receiving yards (386). 
Passed Harold Jackson and moved to 14th in franchise history in receiving yards in 2023.
Moved to ninth all-time in franchise history receptions during the 2023 season.
Passed Preston Dennard, Robert Woods and Flipper Anderson in touchdown receptions and moved to 14th in team history in 2025.
Was second on the team in receptions (61) and third in receiving yards (560) in the 2021 campaign.
Registered a career-best 69 receptions for 734 yards during the regular season in 2019.
Became the first tight end in franchise history to have three-consecutive 100-plus yard receiving games and set the single-season franchise record for receptions by a tight end in 2019.
Recorded four consecutive games with more than 100-yards receiving from Week 13-16 during the 2019 season.
Recorded back-to-back seasons with at least five touchdown receptions in 2020 and 2021.
Hauled in six catches for 55 yards and two touchdowns in the NFC Championship Game against the 49ers last postseason.
Became the 13th tight end in franchise history to record over 1,000 receiving yards in their career.
Registered a career-best 12 catches on the road against the Dallas Cowboys during the 2019 campaign.
Had seven receptions for a career-best 116 yards against the Seattle Seahawks in Week 14 of the 2019 season.
Hauled in three touchdown receptions, a career-high, in Philadelphia against the Eagles in Week 2 of the 2020 season.
Tyler Higbee
HipDoubtful
NFL CAREER


Has appeared in 42 regular season games (40 starts) and played 2,468 total snaps at left guard. Has also started in six postseason contests with 383 snaps played. 
Started 13-of-15 games during the 2025 regular season and played 799 total snaps. 
Finished the 2025 season ranked eighth in Offensive Grade (76.8) and ninth in Run Blocking Grade (74.1) among all guards (min 50% snaps), according to Pro Football Focus. Allowed only 1.0 sack on 450 pass blocking snaps during the regular season. 
Started all 10 regular season games played in 2024 and logged 1,094 offensive snaps.
Started all 17 regular season games his rookie season and finished among the leaders on the team in snaps played (1,094). It was the most snaps for a Rams offensive lineman since 2021 and the most by a Rams rookie since Cooper Kupp in 2017.
Among rookie offensive linemen in the 2023 draft class, he ranked second in most snaps played.
Finished the 2023 season with the second-best pass blocking grade, the fifth-best offensive grade, and the 10th-best run blocking grade among rookie offensive linemen, according to PFF. 
Among rookie guards, Avila finished fifth in sacks allowed (2.0) in 2023.
Was voted to the PWFA All-Rookie Team in ‘23.
Steve Avila
AnkleNot_Listed
NFL CAREER


Has appeared in 86 career regular season games (23 starts) and notched 130 receptions for 1,320 yards and 13 touchdowns.
Has played in six postseason games (five starts) and notched 15 catches for 188 yards and two touchdowns.
Set the single-season franchise record for receiving touchdowns by a tight end (eight) during the 2025 season. It also was tied for the second-most among tight ends in the NFL in 2025. 
Recorded six receiving touchdowns in a six-game span in 2025 from Weeks 10-15. It also tied for the most receiving touchdowns in a single season for a tight end in franchise history. 
Recorded receiving touchdowns in three consecutive games for the first time in his career in Weeks 10-12 of the 2025 season. 
Set a career-high in receptions (43), receiving yards (408) and touchdown receptions (eight) during the 2025 season. His eight touchdown receptions ranked 11th in the NFL. 
Recorded a single-game career-best 75 receiving yards in Week 15 of the 2025 season vs. Detroit. 
Caught the game-winning touchdown in the Wild Card Round Carolina during the 2025 postseason. 
Has two multi-touchdown games in his career. 
Had two touchdown receptions in a three-game stretch to close out the 2023 season.
Had the 20th-highest run blocking grade (64.1) among tight ends in 2023, according to Pro Football Focus.
Notched a career-best 322 receiving yards during the 2022 season.
Had a career-high 45 receiving yards in Week 16 against the Chiefs at the conclusion of the 2022 season.
Had the 14th-best run blocking grade (66.9) among tight ends during the 2022 season, according to PFF.
Colby Parkinson
ShoulderNot_Listed
NFL CAREER


Has appeared in 34 regular season games (12 starts) and recorded 138 tackles (89 solo), six interceptions with 176 interception return yards, one defensive touchdown, 12 passes defended, six pass breakups, one tackle for loss, five pressures, three hurries, two quarterback hits, one forced fumble and three fumble recoveries.
Has appeared in five postseason contests (three starts) and recorded 23 tackles (15 solo), 1.0 sack, one tackle for loss, one quarterback hit, one pressure, two pass breakups and one pass defended. 
Had the third-highest Defensive Grade (90.4) among all defenders in the Divisional Round of the 2025 postseason, according to Pro Football Focus. He also finished with the second-highest Tackling Grade (84.7) and sixth-highest Coverage Grade (87.9). 
Finished with a postseason career-high seven tackles (four solo) to go along with one pass breakup and one pass defended in the Divisional Round at Chigago during the 2025 playoffs.
His six interceptions over the past two seasons are tied for the seventh-most in the NFL over that span. 
Has two career games with two interceptions against the Seahawks. His four career interceptions agains the Seahawks are the most by any Rams player all-time. It's also tied for the most interceptions by any active NFL player against the Seahawks with Jalen Ramsey. 
Became the the first rookie defensive back to win multiple Defensive Player of the Week Awards in 2024.
Was named NFC Defensive Player of the Week in Week 11 after notching eight tackles (six solo), one tackle for loss, one forced fumble and one interception in New England vs. the Patriots. Became the first rookie since 2000 with an interception, a tackle for loss, forced fumble and five or more tackles in a game.
Was named NFC Defensive Player of the Week after recording three tackles (all solo), two interceptions with one returned 103 yards for a touchdown and two passes defended in a Week 9 win against the Seattle Seahawks.
Notched a career-high 10 combined tackles in Week 2 of the 2025 season against the Tennessee Titans. 
Finished the 2025 season ranked 14th in Defensive Grade (72.9) and 10th in Coverage Grade (75.0) among NFL safeties (min 50% snaps), according to Pro Football Focus. His coverage grade also ranked 19th among all secondary defenders.
Finished tied for fifth in the NFL with two fumble recoveries during the 2025 season.
Kamren Kinchens
ShoulderNot_Listed

Watching the West

As the Rams kick off Week 5, there's a three-way tie for first place atop the division at 3-1. Of the five collective losses between the four teams, three have been head-to-head. There continues to be a very viable case to be made that the Rams are defending their crown in the toughest division in football.

San Francisco is about to start a stretch of four road games in five weeks. Here's the upcoming schedule for the 49ers, and yet another reason why a win over San Francisco in prime time could be so consequential: At Tampa next, then home to Atlanta in Week 7. Every rivalry game against them matters, but this one is about as high leverage as an early October contest can possibly be.

Aside from our showdown at SoFi Stadium Thursday, the Seahawks and Cardinals will both be home this Sunday and well-rested after playing TNF last week. Seattle welcomes Tampa Bay in a matchup of 3-1 NFC contenders. Arizona (2-2) will look to reset its season against the lowly Titans (0-4) .

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