Rams vs. Bills Game Center

From Los Angeles Rams running back Darrell Henderson Jr's big run against the Buffalo Bills to wide receiver Cooper Kupp's one-handed catch against the Dallas Cowboys, here are the top five offensive plays from the first 6 weeks of the season.

Watch highlights of the Los Angeles Rams' best plays as they faced the Buffalo Bills, Atlanta Falcons, Arizona Cardinals & San Francisco 49ers in the first four weeks of the 2022 NFL regular season.

Members of the Watts Rams joined Rams Owner/Chairman E. Stanley Kroenke, Chief Operating Officer Kevin Demoff, General Manager Les Snead, 2021 Walter Payton NFL Man of the Year Andrew Whitworth, and Rams former wide receiver Odell Beckham Jr. on-field at SoFi Stadium, for the celebration and Super Bowl LVI Champions banner reveal.

In the season premiere of The Coach McVay Show, Los Angeles Rams head coach Sean McVay is joined by J.B. Long & D'Marco Farr as the team turns the corner on the matchup against the Bills and starts to focus on their upcoming game against the Falcons in Week 2.

Dwayne "The Rock" Johnson, Ozzy Osbourne, Torry Holt, and other notable celebs were spotted at SoFi Stadium for the Los Angeles Rams vs. Buffalo Bills season opener. Take a look at photos from the game!

Look through photos of Los Angeles Rams Cheerleaders in the first regular season game at SoFi Stadium against the Buffalo Bills.

Take a look through some of the best photos from the Los Angeles Rams' season opener against the Buffalo Bills at SoFi Stadium.

Los Angeles Rams fans showed up for the Rams' season opener against the Buffalo Bills. Take a look at some of the best fan moments from Week 1 at SoFi Stadium.

Listen in as Los Angeles Rams wide receiver Cooper Kupp was mic'd up during the season opener against the Buffalo Bills.

Rams head coach Sean McVay discusses the latest on the status of RB Kyren Williams, C Brian Allen, LT Joe Noteboom and LS Matthew Orzech coming out of Thursday night's 2022 season opener against the Bills, as well as his final takeaways from the contest as the team transitions into preparing for Week 2 against the Falcons.

Take a look behind the scenes at the making of the Los Angeles Rams Different Season Same Beast kickoff trailer.

Matthew Stafford no tuvo buena protección en el juego de apertura al sufrir 7 capturas y verse incómodo todo el partido

Los Angeles Rams wide receiver Cooper Kupp talks about making corrections and the attitude the team must take after tonight's Week 1 loss against the Buffalo Bills.

Los Angeles Rams defensive back Nick Scott talks about the defense's execution in tonight's matchup against the Buffalo Bills at SoFi Stadium.

Los Angeles Rams offensive tackle Rob Havenstein talks about tonight's loss to the Buffalo Bills and the benefit of having more days than usual before Week 2's Atlanta Falcons matchup at SoFi Stadium.

Key quotes and notes from Rams head coach Sean McVay and quarterback Matthew Stafford's postgame press conferences following the team's 31-10 loss to the Bills Thursday night at SoFi Stadium.

Watch all of Los Angeles Rams wide receiver Cooper Kupp's catches from his 128-yard game in the season opener against the Buffalo Bills in Week 1 of the 2022 NFL regular season.

Hoy en Vamos Rams, Troy Santiago y Ricardo Lopez hablan sobre la derrota ante los Bills de Buffalo y cómo pueden mejorar los Rams de Los Angeles para la próxima semana contra los Falcons.

Rams head coach Sean McVay discusses the team's 31-10 Week 1 loss to the Bills Thursday night at SoFi Stadium, including the performance of QB Matthew Stafford, what he saw from the Rams' offensive line, and responding to the result.

Rams QB Matthew Stafford talks about what he took away from his performance in Thursday night's 31-10 loss to the Bills, including what he saw from the Bills defense and what he can do to play better moving forward.

Rams defense generates four takeaways in loss.

Los Angeles Rams quarterback Matthew Stafford connects with wide receiver Cooper Kupp for a 23-yard gain against the Buffalo Bills.

Los Angeles Rams kicker Matt Gay kicks a 57-yard field goal, his longest with the Rams, right before halftime against the Buffalo Bills.

Los Angeles Rams cornerback Troy Hill intercepts Buffalo Bills quarterback Josh Allen for first INT of the season.

Los Angeles Rams linebacker Bobby Wagner sacks Buffalo Bills quarterback Josh Allen for his first sack as a member of the Rams.